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Elntm1Dyl
Targeted Allele Detail
Nomenclature
Symbol: Elntm1Dyl
Name: elastin; targeted mutation 1, Dean Y Li
MGI ID: MGI:2153007
Synonyms: Eln-
Gene: Eln  Location: Chr5:134703781-134747241 bp, - strand  Genetic Position: Chr5, 74.76 cM
Reduced vessel extensibility in the Fbln5tm1Eno/Fbln5tm1Eno and Elntm1Dyl/Eln+ carotid artery

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47771
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eln Mutation:  0 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Aortic Valve Disease inHeterozygous mice (J:184494)

References
Original:  J:47771 Li DY, et al., Elastin is an essential determinant of arterial morphogenesis. Nature. 1998 May 21;393(6682):276-80
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory