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Targeted Allele Detail
Symbol: Dcntm1Ioz
Name: decorin; targeted mutation 1, Renato V Iozzo
MGI ID: MGI:2153002
Synonyms: Dcn-
Gene: Dcn  Location: Chr10:97479500-97518162 bp, + strand  Genetic Position: Chr10, 50.27 cM
Dcntm1Ioz/Dcntm1Ioz mice display thin and fragile skin

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:39212
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation details
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dcn Mutation:  1 strain or line available
Phenotypic Similarity to Human Syndrome: Ehlers-Danlos syndrome (J:39212)
Phenotypic Similarity to Human Syndrome: Ehlers-Danlos syndrome, progeroid type in mice homozygous or hemizygous for for Bgntm1Mfy and homozygous for Dcntm1Ioz (J:91512)
Phenotypic Similarity to Human Syndrome: Preterm premature rupture of fetal membranes (PPROM; J:180914) in mice homozygous for Bgntm1Mfy and Dcntm1Ioz

Original:  J:39212 Danielson KG, et al., Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol. 1997 Feb 10;136(3):729-43
All:  36 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.20
The Jackson Laboratory