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Targeted Allele Detail
Symbol: Dcntm1Ioz
Name: decorin; targeted mutation 1, Renato V Iozzo
MGI ID: MGI:2153002
Synonyms: Dcn-
Gene: Dcn  Location: Chr10:97479500-97518162 bp, + strand  Genetic Position: Chr10, 50.27 cM
Dcntm1Ioz/Dcntm1Ioz mice display thin and fragile skin

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:39212
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that no transcript was detectable in sternum, heart, liver or kidney of homozygous mice. Immunoblot analysis on extracts of tail tissue revealed that no expressed protein was detectable in homozygous mice. (J:39212)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dcn Mutation:  7 strains or lines available
Phenotypic Similarity to Human Syndrome: Ehlers-Danlos syndrome (J:39212)
Phenotypic Similarity to Human Syndrome: Ehlers-Danlos syndrome, progeroid type in mice homozygous or hemizygous for for Bgntm1Mfy and homozygous for Dcntm1Ioz (J:91512)
Phenotypic Similarity to Human Syndrome: Preterm premature rupture of fetal membranes (PPROM; J:180914) in mice homozygous for Bgntm1Mfy and Dcntm1Ioz

Original:  J:39212 Danielson KG, et al., Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol. 1997 Feb 10;136(3):729-43
All:  42 reference(s)

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MGI 6.03
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