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Itgb4tm1Son
Targeted Allele Detail
Nomenclature
Symbol: Itgb4tm1Son
Name: integrin beta 4; targeted mutation 1, Arnoud Sonnenberg
MGI ID: MGI:2152982
Synonyms: beta4-, beta4 null
Gene: Itgb4  Location: Chr11:115974709-116008412 bp, + strand  Genetic Position: Chr11, 80.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33713
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA hygromycin expression cassette replaced a genomic fragment containing exons 1 and 2. RT-PCR analysis demonstrated a lack of transcript in skin tissue of homozygous mice. (J:33713)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Itgb4 Mutation:  58 strains or lines available
References
Original:  J:33713 van der Neut R, et al., Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice. Nat Genet. 1996 Jul;13(3):366-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory