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Targeted Allele Detail
Symbol: Col2a1tm1Prc
Name: collagen, type II, alpha 1; targeted mutation 1, Darwin J Prockop
MGI ID: MGI:2152978
Gene: Col2a1  Location: Chr15:97975602-98004695 bp, - strand  Genetic Position: Chr15, 53.97 cM
Abnormal intervertebral disc development in Col2a1tm1Prc/Col2a1tm1Prc mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:30041
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 35. RT-PCR analysis demonstrated the presence of a transcript that terminated at exon 35. A mature protein was not detected in cultured cartilage cells isolated from homozygous mice. (J:30041)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 6 assay results
In Structures Affected by this Mutation: 33 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col2a1 Mutation:  20 strains or lines available
Original:  J:30041 Li SW, et al., Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone. Genes Dev. 1995 Nov 15;9(22):2821-30
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory