Col9a1tm1Jae
Targeted Allele Detail
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Symbol: |
Col9a1tm1Jae |
Name: |
collagen, type IX, alpha 1; targeted mutation 1, Rudolf Jaenisch |
MGI ID: |
MGI:2152964 |
Gene: |
Col9a1 Location: Chr1:24216691-24291765 bp, + strand Genetic Position: Chr1, 9.95 cM
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Alliance: |
Col9a1tm1Jae page
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Histology of knee joint articular cartilage of wild-type control and Col9a1tm1Jae/Col9a1tm1Jae mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:18628
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Parent Cell Line: |
D3 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: A neomycin selection cassette was inserted into exon 8 in reverse transcriptional orientation relative to the gene. Northern blot analysis on RNA derived from E17.5 homozygous embryos demonstrated that no detectable transcript was produced from this allele. Western blot analysis on extracts of rib cage and vertebral column from homozygous mice confirmed that no stable encoded protein was present.
(J:18628)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Col9a1 Mutation: |
56 strains or lines available
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Original: |
J:18628 Fassler R, et al., Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5070-4 |
All: |
20 reference(s) |
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