T^9J
Spontaneous Allele Detail

Summary

• Symbol: T^9J
• Name: brachyury, T-box transcription factor T; brachyury 9 Jackson
• MGI ID: MGI:2152904
• Synonyms: Tl2
• Gene: T Location: Chr17:8653255-8661328 bp, + strand Genetic Position: Chr17, 4.92 cM
• Alliance: T^9J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: A spontaneous mouse mutant phenotypically similar to brachyury. A complementation test with t^w5 was used to demonstrate allelism.
• Inheritance: Semidominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any T Mutation: 60 strains or lines available

Notes

Tailless progeny were produced by a cross of mice heterozygous for Tl2 and for t^w5, demonstrating that Tl2 is an allele of T (brachyury); it has therefore been renamed brachyury 9 Jackson (T^9J). A cross to qk (quaking) produced no progeny having the quaking phenotype, indicating that if the T^9J mutation, like most dominant T alleles, is a deletion, it does not extend as far distally as the qk locus (5.4 cM).

References

• Original: J:72463 Harris BS, et al., Identification and Mapping of the brachyury-like 2 mouse mutant. MGI Direct Data Submission. 2001
• All: 2 reference(s)