Lhx5^tm1Lmgd
Targeted Allele Detail

Summary

• Symbol: Lhx5^tm1Lmgd
• Name: LIM homeobox protein 5; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
• MGI ID: MGI:2152620
• Synonyms: Lhx5^-, Lhx5 KO
• Gene: Lhx5 Location: Chr5:120569764-120579288 bp, + strand Genetic Position: Chr5, 60.62 cM
• Alliance: Lhx5^tm1Lmgd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55103
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 2, 3, and 4 of the gene, which encode the second LIM domain and the homeodomain of the protein. (J:55103)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhx5 Mutation: 18 strains or lines available

References

• Original: J:55103 Zhao Y, et al., Control of hippocampal morphogenesis and neuronal differentiation by the LIM homeobox gene Lhx5. Science. 1999 May 14;284(5417):1155-8
• All: 7 reference(s)