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Targeted Allele Detail
Symbol: Gnai3tm1Rmm
Name: guanine nucleotide binding protein (G protein), alpha inhibiting 3; targeted mutation 1, Richard M Mortensen
MGI ID: MGI:2152618
Gene: Gnai3  Location: Chr3:108107280-108146146 bp, - strand  Genetic Position: Chr3, 46.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:68045
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 1. Western analysis confirmed the elimination of expression in homozygous mice and detected no compensatory changes in other pertussis toxin sensitive G proteins. (J:68045)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnai3 Mutation:  22 strains or lines available
Original:  J:68045 Jain M, et al., Targeted inactivation of Galpha(i) does not alter cardiac function or beta-adrenergic sensitivity. Am J Physiol Heart Circ Physiol. 2001 Feb;280(2):H569-75
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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