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Nrltm1Asw
Targeted Allele Detail
Summary
Symbol: Nrltm1Asw
Name: neural retina leucine zipper gene; targeted mutation 1, Anand Swaroop
MGI ID: MGI:2152376
Synonyms: cone-full, Nrl-
Gene: Nrl  Location: Chr14:55756435-55762438 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance: Nrltm1Asw page
Adult rods are reprogrammed into cone-like cells in Nrltm1.1Jcco/Nrltm1.1Jcco and Nrltm1Asw/Nrltm1Asw retinas

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71808
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced the entire coding region (exons 2 and 3). Immunoblot analysis did not detect protein in retina from 10 day old homozygous mutant mice. RT-PCR studies of retina from 10 day old homozygous mutant mice did not detect mRNA. (J:78692)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 52054 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nrl Mutation:  13 strains or lines available
References
Original:  J:71808 Swain PK, et al., Multiple phosphorylated isoforms of NRL are expressed in rod photoreceptors. J Biol Chem. 2001 Sep 28;276(39):36824-30
All:  117 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory