About   Help   FAQ
Apoetm1Lmh
Targeted Allele Detail
Summary
Symbol: Apoetm1Lmh
Name: apolipoprotein E; targeted mutation 1, Louis M Havekes
MGI ID: MGI:2152302
Synonyms: apoe-, Apoe0
Gene: Apoe  Location: Chr7:19430034-19433113 bp, - strand  Genetic Position: Chr7, 9.94 cM
Alliance: Apoetm1Lmh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22347
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA hygromycin B resistance cassette replaced exons 1, 2, and part of 3 of the gene. Northern blots of liver from homozygous mutant mice showed no detectable transcript. Western blots from homozygous mutant mice showed no detectable protein. (J:22347)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  146 strains or lines available
References
Original:  J:22347 van Ree JH, et al., Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis. 1994 Nov;111(1):25-37
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory