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Targeted Allele Detail
Symbol: Apoetm1Lmh
Name: apolipoprotein E; targeted mutation 1, Louis M Havekes
MGI ID: MGI:2152302
Synonyms: apoe-, Apoe0
Gene: Apoe  Location: Chr7:19696109-19699188 bp, - strand  Genetic Position: Chr7, 9.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:22347
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA hygromycin B resistance cassette replaced exons 1, 2, and part of 3 of the gene. Northern blots of liver from homozygous mutant mice showed no detectable transcript. Western blots from homozygous mutant mice showed no detectable protein. (J:22347)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apoe Mutation:  128 strains or lines available
Original:  J:22347 van Ree JH, et al., Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis. 1994 Nov;111(1):25-37
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory