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Ptf1atm1Pkwe
Targeted Allele Detail
Nomenclature
Symbol: Ptf1atm1Pkwe
Name: pancreas specific transcription factor, 1a; targeted mutation 1, Peter K Wellauer
MGI ID: MGI:2152066
Synonyms: p48 -
Gene: Ptf1a  Location: Chr2:19445663-19447501 bp, + strand  Genetic Position: Chr2, 13.37 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:51571
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into exon 1 upstream of the sequences encoding the bHLH region. RT-PCR analysis failed to detect any mRNA derived from this mutant allele in homozygous mice. (J:51571)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptf1a Mutation:  6 strains or lines available
References
Original:  J:51571 Krapp A, et al., The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas. Genes Dev. 1998 Dec 1;12(23):3752-63
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory