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Prkcetm1Msg
Targeted Allele Detail
Nomenclature
Symbol: Prkcetm1Msg
Name: protein kinase C, epsilon; targeted mutation 1, Robert Messing
MGI ID: MGI:2152043
Synonyms: PKC-epsilon-, PKCepsilon-
Gene: Prkce  Location: Chr17:86167785-86657919 bp, + strand  Genetic Position: Chr17, 56.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57887
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details1.2 kb of this gene including the translation initiation site was deleted via homologous recombination with a neo-derived targeting vector. Western blot indicated homozygous mutant animals did not express protein in dorsal root ganglion. (J:57887)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkce Mutation:  26 strains or lines available
References
Original:  J:57887 Khasar SG, et al., A novel nociceptor signaling pathway revealed in protein kinase C epsilon mutant mice. Neuron. 1999 Sep;24(1):253-60
All:  45 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory