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Dock2tm1Tsas
Targeted Allele Detail
Nomenclature
Symbol: Dock2tm1Tsas
Name: dedicator of cyto-kinesis 2; targeted mutation 1, Takehiko Sasazuki
MGI ID: MGI:2152031
Synonyms: Dock2-
Gene: Dock2  Location: Chr11:34226815-34783892 bp, - strand  Genetic Position: Chr11, 19.68 cM, cytoband A5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71005
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 3.1kb of sequence that includes part of exon 3 through exon 5. Western blot analysis did not detect protein in the spleen and thymus of homozygous mice. (J:71005)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dock2 Mutation:  86 strains or lines available
References
Original:  J:71005 Fukui Y, et al., Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature. 2001 Aug 23;412(6849):826-31
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory