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Tg(APPV717F)109Ili
Transgene Detail
Nomenclature
Symbol: Tg(APPV717F)109Ili
Name: transgene insertion 109, Ivan Lieberburg
MGI ID: MGI:2151935
Synonyms: APPInd, APPV717F, hAPP+, hbeta-APP, PDAPP, PDAPP+, PDAPP-109, PD-APP transgenic, PDAPP-V717F, PDGF-hAPP(V717F)
Transgene: Tg(APPV717F)109Ili  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(APPV717F)109Ili expresses 1 gene
 
Mutation detailsOverexpression of a human APP (hAPP) minigene encoding the APP717V to F mutation associated with familial Alzheimer's Disease. The construct contained APP introns 6 - 8, allowing alternative splicing of exons 7 and 8. The transgene utilizes a platelet-derived growth factor promoter (PDGF-b) and the three major splicing variants of hAPP mRNA were expressed in transgenic mice. As determined by RNAse protection, line 109 expressed ~ 18-fold more APP than previously described neuron-specific enolase (NSE)-promoter-driven APP transgenes. (J:23080, J:100980)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:23080 Games D, et al., Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein [see comments]. Nature. 1995 Feb 9;373(6514):523-7
All:  96 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/25/2015
MGI 5.21
The Jackson Laboratory