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Targeted Allele Detail
Symbol: Hoxa1tm3.1Mrc
Name: homeobox A1; targeted mutation 3.1, Mario R Capecchi
MGI ID: MGI:2151686
Synonyms: Hoxa1GFPlox
Gene: Hoxa1  Location: Chr6:52155590-52158317 bp, - strand  Genetic Position: Chr6, 25.4 cM
Germline Transmission:  Earliest citation of germline transmission: J:50569
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsInsertion of a eGFP gene in-frame to sequences encoding the Hoxa1 gene. An adjacent loxP-flanked neomycin cassette was removed via Cre-mediated recombination in mice in this derivative of Hoxa1tm3Mrc. A Hoxa1-eGFP fusion protein is expressed from this allele in a pattern identical to that predicted by in situ hybridization analysis. (J:50569)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 17 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:  8 strains or lines available
Original:  J:50569 Godwin AR, et al., Detection of targeted GFP-Hox gene fusions during mouse embryogenesis. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13042-7
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory