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Gna11tm1Soff
Targeted Allele Detail
Nomenclature
Symbol: Gna11tm1Soff
Name: guanine nucleotide binding protein, alpha 11; targeted mutation 1, Stefan Offermanns
MGI ID: MGI:2151589
Synonyms: Galpha11-, Gna11-
Gene: Gna11  Location: Chr10:81528724-81545162 bp, - strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49140
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exons 3, 4 and part of 5, which encodes the amino acids that contribute to the guanine nucleotide binding pocket. Western blot analysis on extracts of brain, spleen and testis tissues did not detect any protein expressed from this allele in homozyogous mice. (J:49140)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 37 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gna11 Mutation:  4 strains or lines available
Notes
ES cell line = AB1 (129S7/SvEvBrd-Hprt+) or JH1 (129S7/SvEvBrd).
References
Original:  J:49140 Offermanns S, et al., Embryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice. EMBO J. 1998 Aug 3;17(15):4304-12
All:  53 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory