Nr2e1^tm1Gsc
Targeted Allele Detail

Summary

• Symbol: Nr2e1^tm1Gsc
• Name: nuclear receptor subfamily 2, group E, member 1; targeted mutation 1, Gunther Schutz
• MGI ID: MGI:2151350
• Synonyms: tlx-
• Gene: Nr2e1 Location: Chr10:42437959-42459628 bp, - strand Genetic Position: Chr10, 22.89 cM
• Alliance: Nr2e1^tm1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44679
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neomycin cassette replaced exons 2 and 3, which encode two zinc fingers. Northern analysis and RNAse protection assays were used to demonstrate successful disruption of the gene. (J:44679)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr2e1 Mutation: 32 strains or lines available

References

• Original: J:44679 Monaghan AP, et al., Defective limbic system in mice lacking the tailless gene. Nature. 1997 Dec 4;390(6659):515-7
• All: 8 reference(s)