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Targeted Allele Detail
Symbol: Gnaltm1Rax
Name: guanine nucleotide binding protein, alpha stimulating, olfactory type; targeted mutation 1, Richard Axel
MGI ID: MGI:2151207
Synonyms: Galphaolf, G-olf-
Gene: Gnal  Location: Chr18:67088298-67226792 bp, + strand  Genetic Position: Chr18, 39.85 cM
Germline Transmission:  Earliest citation of germline transmission: J:45534
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA Pgk-neomycin resistance cassette replaced 1.65kb of sequence that includes the first four exons of the gene. RNA in situ hybridization analysis did not detect transcripts in olfactory sensory neurons of 5-day old homozygous mutant mice. Immunohistochemistry analysis showed reduced staining on olfactory bulb sections derived from 5-day old homozygous mutant mice. (J:45534)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnal Mutation:  4 strains or lines available
Original:  J:45534 Belluscio L, et al., Mice deficient in G(olf) are anosmic. Neuron. 1998 Jan;20(1):69-81
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory