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Targeted Allele Detail
Symbol: Scxtm1Eno
Name: scleraxis; targeted mutation 1, Eric N Olson
MGI ID: MGI:2150910
Synonyms: scleraxis -
Gene: Scx  Location: Chr15:76457452-76459458 bp, + strand  Genetic Position: Chr15, 35.92 cM
Germline Transmission:  Earliest citation of germline transmission: J:55991
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA LacZ-PGK-neomycin resistance cassette inserted in-frame with the initiation codon replaced all except the 13 most distal residues of the first exon, which encodes the bHLH region. RT-PCR and whole mount in situ studies did not detect transcripts in homozygous mutant embryos. The lacZ reporter is non-functional. (J:55991)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scx Mutation:  2 strains or lines available
ES cell line = AB1 (129S7/SvEvBrd-Hprt+) or AB2.2 (129S7/SvEvBrd-Hprtb-m2)
Original:  J:55991 Brown D, et al., Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999 Oct;126(19):4317-29
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory