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Targeted Allele Detail
Symbol: Ppp3catm1Jse
Name: protein phosphatase 3, catalytic subunit, alpha isoform; targeted mutation 1, Jonathan G Seidman
MGI ID: MGI:2150749
Synonyms: Aalpha-, CNAa-, CnA alpha (_), CnA-alpha-
Gene: Ppp3ca  Location: Chr3:136375885-136643488 bp, + strand  Genetic Position: Chr3, 63.34 cM
Germline Transmission:  Earliest citation of germline transmission: J:71750
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin cassette was inserted into the exon encoding nucleotides 572 - 717 of the mRNA sequence of the gene. This exon encodes part of the catalytic domain of the protein. Western blots of T cell extracts from homozygous mutant mice showed no detectable peptide. (J:71750)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ppp3ca Mutation:  43 strains or lines available
Original:  J:71750 Zhang BW, et al., T cell responses in calcineurin A alpha-deficient mice. J Exp Med. 1996 Feb 1;183(2):413-20
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory