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Ppp3catm1Jse
Targeted Allele Detail
Nomenclature
Symbol: Ppp3catm1Jse
Name: protein phosphatase 3, catalytic subunit, alpha isoform; targeted mutation 1, Jonathan G Seidman
MGI ID: MGI:2150749
Synonyms: Aalpha-, CNAa-, CnA alpha (_), CnA-alpha-
Gene: Ppp3ca  Location: Chr3:136670124-136937727 bp, + strand  Genetic Position: Chr3, 63.34 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71750
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into the exon encoding nucleotides 572 - 717 of the mRNA sequence of the gene. This exon encodes part of the catalytic domain of the protein. Western blots of T cell extracts from homozygous mutant mice showed no detectable peptide. (J:71750)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ppp3ca Mutation:  17 strains or lines available
References
Original:  J:71750 Zhang BW, et al., T cell responses in calcineurin A alpha-deficient mice. J Exp Med. 1996 Feb 1;183(2):413-20
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory