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Targeted Allele Detail
Symbol: Fgf8tm1.4Mrt
Name: fibroblast growth factor 8; targeted mutation 1.4, Gail R Martin
MGI ID: MGI:2150348
Synonyms: Fgf8-, Fgf8del, Fgf8delta, Fgf8delta2,3, Fgf8null
Gene: Fgf8  Location: Chr19:45736798-45742915 bp, - strand  Genetic Position: Chr19, 38.75 cM, cytoband C3-D
Germline Transmission:  Earliest citation of germline transmission: J:45909
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Fgf8tm1.3Mrt in which mice carrying this allele were mated to beta-actin cre mice, which resulted in heterozygous offspring carrying a recombined Fgf8 allele in which both the neomycin resistance cassette and exons 2 and 3 were deleted. (J:45909)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 53 assay results
In Structures Affected by this Mutation: 35 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fgf8 Mutation:  11 strains or lines available
Original:  J:45909 Meyers EN, et al., An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet. 1998 Feb;18(2):136-41
All:  52 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory