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Targeted Allele Detail
Symbol: Avpr2tm1Jwe
Name: arginine vasopressin receptor 2; targeted mutation 1, Jurgen Wess
MGI ID: MGI:2150344
Synonyms: Avpr2E242X, V2R-
Gene: Avpr2  Location: ChrX:73891765-73894428 bp, + strand  Genetic Position: ChrX, 37.46 cM
Pelvic space of Avpr2tm1Jwe/Y pups is enlarged in kidneys

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:66094
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsA neomycin resistance cassette was inserted into the second intron of the gene, splitting codon 304. This cassette was flanked by two loxp sequences, which enabled the removal of the neo cassette from the mouse genome when desired. In addition, a Glu 242 stop nonsense mutation (GAA to TAG; E242X) was introduced by PCR-based site-directed mutagenesis, resulting in an Avpr2 protein that is truncated within the third intracellular loop and is functionally inactive. (J:66094)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Avpr2 Mutation:  2 strains or lines available
Original:  J:66094 Yun J, et al., Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene. J Clin Invest. 2000 Dec;106(11):1361-71
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory