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Targeted Allele Detail
Symbol: Ephb2tm1Paw
Name: Eph receptor B2; targeted mutation 1, Tony Pawson
MGI ID: MGI:2149765
Synonyms: EphB2-, EphB2delta, Ephb2KO, Nuk1
Gene: Ephb2  Location: Chr4:136647539-136835988 bp, - strand  Genetic Position: Chr4, 69.0 cM, cytoband D-E
Germline Transmission:  Earliest citation of germline transmission: J:34200
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced 1.4kb of sequence including the exon that encodes amino acids 29-50, and introduced a frame shift downstream of the insertion. In an immune-complex in vitro tyrosine kinase assay, antiserum raised against the C-terminal of the protein did not detect wild-type protein in lysates of homozygous mutant E10.5 embryos. (J:34200)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 14 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ephb2 Mutation:  41 strains or lines available
Original:  J:34200 Henkemeyer M, et al., Nuk controls pathfinding of commissural axons in the mammalian central nervous system. Cell. 1996 Jul 12;86(1):35-46
All:  54 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory