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Targeted Allele Detail
Symbol: Irs4tm1Lhd
Name: insulin receptor substrate 4; targeted mutation 1, Gustav E Lienhard
MGI ID: MGI:2149726
Synonyms: Irs4-, IRS-4 null
Gene: Irs4  Location: ChrX:141710998-141725263 bp, - strand  Genetic Position: ChrX, 62.43 cM
Germline Transmission:  Earliest citation of germline transmission: J:59964
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the entire coding sequence of the gene except for 457 bp at the 3' end. Reverse transcription-PCR detected no mRNA expression in brain, skeletal muscle, kidney, or liver of homozygous mutant mice. (J:59964)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irs4 Mutation:  6 strains or lines available
Original:  J:59964 Fantin VR, et al., Mice lacking insulin receptor substrate 4 exhibit mild defects in growth, reproduction, and glucose homeostasis. Am J Physiol Endocrinol Metab. 2000 Jan;278(1):E127-33
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory