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Slc2a4tm1Mch
Targeted Allele Detail
Nomenclature
Symbol: Slc2a4tm1Mch
Name: solute carrier family 2 (facilitated glucose transporter), member 4; targeted mutation 1, Maureen J Charron
MGI ID: MGI:2149725
Synonyms: GLUT-4 null
Gene: Slc2a4  Location: Chr11:69942539-69948188 bp, - strand  Genetic Position: Chr11, 42.93 cM, cytoband C-E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49328
Parent Cell Line:  WW6 (ES Cell)
Strain of Origin:  STOCK 129/Sv and C57BL/6J and SJL
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 10 of the gene, disrupting expression. Loss of expression was shown by Northern and Western blots of skeletal muscle. (J:49328)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc2a4 Mutation:  20 strains or lines available
References
Original:  J:49328 Katz EB, et al., Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4 [see comments]. Nature. 1995 Sep 14;377(6545):151-5
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory