About   Help   FAQ
Targeted Allele Detail
Symbol: Hes1tm1Fgu
Name: hes family bHLH transcription factor 1; targeted mutation 1, Francois Guillemot
MGI ID: MGI:2149672
Synonyms: Hes1-
Gene: Hes1  Location: Chr16:30064384-30067796 bp, + strand  Genetic Position: Chr16, 21.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:30431
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced the first three exons including sequences encoding the bHLH region of HES1. Northern blot analysis did not detect transcript in E9.5 homozygous mutant embryos. (J:30431)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 69 assay results
In Structures Affected by this Mutation: 26 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hes1 Mutation:  13 strains or lines available
Original:  J:30431 Ishibashi M, et al., Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev. 1995 Dec 15;9(24):3136-48
All:  65 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.12
The Jackson Laboratory