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Pik3r1tm1Dfr
Targeted Allele Detail
Nomenclature
Symbol: Pik3r1tm1Dfr
Name: phosphoinositide-3-kinase regulatory subunit 1; targeted mutation 1, David A Fruman
MGI ID: MGI:2149438
Synonyms: p85alpha-, p85a-p55a-p50a-
Gene: Pik3r1  Location: Chr13:101680563-101768217 bp, - strand  Genetic Position: Chr13, 53.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52229
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced the last five exons (11 - 15) of the gene, which are common to all known splice variants. (J:52229)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3r1 Mutation:  42 strains or lines available
References
Original:  J:52229 Fruman DA, et al., Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha. Science. 1999 Jan 15;283(5400):393-7
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2018
MGI 6.12
The Jackson Laboratory