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Psen2tm1Bdes
Targeted Allele Detail
Nomenclature
Symbol: Psen2tm1Bdes
Name: presenilin 2; targeted mutation 1, Bart de Strooper
MGI ID: MGI:2149117
Synonyms: PS2-
Gene: Psen2  Location: Chr1:180227004-180263438 bp, - strand  Genetic Position: Chr1, 84.19 cM
Phenotypical analysis of Psen2tm1Bdes/Psen2tm1Bdes mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58118
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Psen2 Mutation:  6 strains or lines available
References
Original:  J:58118 Herreman A, et al., Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory