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Insl3tm1Par
Targeted Allele Detail
Summary
Symbol: Insl3tm1Par
Name: insulin-like 3; targeted mutation 1, Luis F Parada
MGI ID: MGI:2148889
Synonyms: Insl3-
Gene: Insl3  Location: Chr8:72141896-72143221 bp, + strand  Genetic Position: Chr8, 34.43 cM
Alliance: Insl3tm1Par page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55881
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ-PGK-neomycin resistance cassette replaced a 1190 bp region containing the complete coding sequence for the gene. In situ studies of testis did not detect Insl3 expression in Leydig cells from homozygous mutant mice. Expression of the inserted lacZ gene was not reported. (J:55881)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Insl3 Mutation:  7 strains or lines available
References
Original:  J:55881 Nef S, et al., Cryptorchidism in mice mutant for Insl3. Nat Genet. 1999 Jul;22(3):295-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory