Clcnka^tm1Suc
Targeted Allele Detail

Summary

• Symbol: Clcnka^tm1Suc
• Name: chloride channel, voltage-sensitive Ka; targeted mutation 1, Shinichi Uchida
• MGI ID: MGI:2148676
• Synonyms: Clcnk1-
• Gene: Clcnka Location: Chr4:141111922-141126017 bp, - strand Genetic Position: Chr4, 73.94 cM
• Alliance: Clcnka^tm1Suc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:51917
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Insertion of a PGK-neomycin resistance cassette replaced approximately 8kb of the gene, deleting exons 1-8. Homozygous mutant mice did not express Clcnk1 mRNA on a ribonuclease protection assay. Absence of protein was verified by immunohistochemistry of mouse kidney. (J:51917)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clcnka Mutation: 21 strains or lines available

References

• Original: J:51917 Matsumura Y, et al., Overt nephrogenic diabetes insipidus in mice lacking the CLC-K1 chloride channel [see comments]. Nat Genet. 1999 Jan;21(1):95-8
• All: 6 reference(s)