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Krt14tm1.1(cre)Wbm
Targeted Allele Detail
Nomenclature
Symbol: Krt14tm1.1(cre)Wbm
Name: keratin 14; targeted mutation 1.1, Walter Birchmeier
MGI ID: MGI:2148597
Synonyms: K14-cre(deltaneo)
Gene: Krt14  Location: Chr11:100203162-100207510 bp, - strand  Genetic Position: Chr11, 63.43 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:69463
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Mutation detailsA cre gene was inserted in frame into the gene immediately following the endogenous start codon. An frt-flanked neomycin selection cassette that was inserted following the cre gene was removed by Flp-mediated recombination in ES cells prior to production of chimeric mice. This promoter is active after birth in the epidermis and hair follicles as well as the eye, tongue, and esophagus. (J:69463)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Krt14     Summary of all recombinase alleles driven by Krt14. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Krt14 Mutation:  6 strains or lines available
References
Original:  J:69463 Huelsken J, et al., beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001 May 18;105(4):533-45
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory