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Ctnnb1tm2Kem
Targeted Allele Detail
Summary
Symbol: Ctnnb1tm2Kem
Name: catenin beta 1; targeted mutation 2, Rolf Kemler
MGI ID: MGI:2148567
Synonyms: B-cateninfl2-6, BcatLOF, Beta-Catc, beta-cateninc, beta-catenindeltaex2-6-fl, beta-cateninf, beta-cateninfl, beta-cateninflox, beta-cateninfloxed, beta-cateninlox, beta-catenin/loxP(ex2-6), beta-catex2-6, beta-catfl, beta-Catflox, beta-catlof, betaCatN, beta-Ctnfl, Catnb1tm2Kem, Catnbfx, Catnblox(ex2-6), Catnbtm2Kem, Catnbtm2Kwem, CtnbfloxE2-E6, Ctnnb1f, Ctnnb1fl, Ctnnb1flox, Ctnnb1floxed, Ctnnb1fx, Ctnnb1loxp
Gene: Ctnnb1  Location: Chr9:120762466-120789573 bp, + strand  Genetic Position: Chr9, 72.19 cM
Alliance: Ctnnb1tm2Kem page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:67966
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted in intron 1 and a loxP-flanked neomycin-TK cassette was inserted downstream in intron 6. The neomycin-TK cassette was removed by transient transfection with a Cre recombinase expression vector in ES cells prior to the production of chimeric mice and left two loxP sites flanking a region of gene sequence from exon 2 through exon 6. (J:67966)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 390 assay results
13 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 105 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ctnnb1tm2Kem
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  49 strains or lines available
References
Original:  J:67966 Brault V, et al., Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development. 2001 Apr;128(8):1253-64
All:  518 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory