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Ptger4tm1Aic
Targeted Allele Detail
Nomenclature
Symbol: Ptger4tm1Aic
Name: prostaglandin E receptor 4 (subtype EP4); targeted mutation 1, Atsushi Ichikawa
MGI ID: MGI:2137851
Synonyms: EP4-, Ptger4-
Gene: Ptger4  Location: Chr15:5206661-5244187 bp, - strand  Genetic Position: Chr15, 1.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47618
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 1.6kb fragment of the coding region of exon 2, which contains the sixth transmembrane domain of the receptor. Northern blot analysis using a cDNA probe specific for exon 2 did not detect transcript in intestine and spleen homozygous mutant neonates. (J:47618)
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptger4 Mutation:  0 strains or lines available
References
Original:  J:47618 Segi E, et al., Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun. 1998 May 8;246(1):7-12
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory