Ptger4^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Ptger4^tm1Sna
• Name: prostaglandin E receptor 4 (subtype EP4); targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:2137851
• Synonyms: EP4-, Ptger4-, Ptger4^tm1Aic
• Gene: Ptger4 Location: Chr15:5262880-5273668 bp, - strand Genetic Position: Chr15, 1.99 cM
• Alliance: Ptger4^tm1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:47618
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced a 1.6kb fragment of the coding region of exon 2, which contains the sixth transmembrane domain of the receptor. Northern blot analysis using a cDNA probe specific for exon 2 did not detect transcript in intestine and spleen homozygous mutant neonates. (J:47618)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptger4^tm1Sna

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptger4 Mutation: 30 strains or lines available

References

• Original: J:47618 Segi E, et al., Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun. 1998 May 8;246(1):7-12
• All: 42 reference(s)