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Targeted Allele Detail
Symbol: Ptger4tm1Bhk
Name: prostaglandin E receptor 4 (subtype EP4); targeted mutation 1, Beverly H Koller
MGI ID: MGI:2137850
Synonyms: EP4-
Gene: Ptger4  Location: Chr15:5233399-5244187 bp, - strand  Genetic Position: Chr15, 1.99 cM
Germline Transmission:  Earliest citation of germline transmission: J:44108
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 1 and 2, which encode the initiation codon and regions of the gene encoding six of the seven transmembrane-spanning domains and putative extracellular loops, were replaced by a neomycin resistance gene. Northern blot analysis of RNA from thymus and spleen of homozygous mutant neonates using cDNA probes specific for this gene verified the loss of expression. (J:44108)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptger4 Mutation:  16 strains or lines available
Phenotypic Similarity to Human Syndrome: Patent Ductus Arteriosus in homozygous mice (J:44108)
Original:  J:44108 Nguyen M, et al., The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature. 1997 Nov 6;390(6655):78-81
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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