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Targeted Allele Detail
Symbol: Thrbtm1.1Syc
Name: thyroid hormone receptor beta; targeted mutation 1.1, Sheue-yann Cheng
MGI ID: MGI:2137592
Synonyms: TRbetaPV, TRbetaPV, TRbeta PV
Gene: Thrb  Location: Chr14:17660960-18038086 bp, + strand  Genetic Position: Chr14, 7.08 cM, cytoband A3
Histology of thyroid glands of wild-type, Thrbtm1.1Syc/Thrb+ and Thrbtm1.1Syc/Thrbtm1.1Syc mice.

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:65885
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsMice homozygous for the Thrbtm1Syc allele were mated to EIIa-Cre transgenic mice to generate mice that carry a germline deletion of the neomycin resistance gene. RT-PCR studies of liver and brown adipocytes from mice homozygous for the final allele indicate that the mutant allele is expressed at the RNA level in expected T3 target tissues. Northern analyses of liver, heart, and brain indicate that levels of transcription of both the mutated and wild-type alleles were not significantly different in heterozygous and homozygous mutant mice, and wild-type mice. (J:65885)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thrb Mutation:  5 strains or lines available
Phenotypic Similarity to Human Syndrome: Follicular Thyroid Carcinoma in homozygous mice (J:92629, J:186140, J:192946, J:198017, J:204327)

Original:  J:65885 Kaneshige M, et al., Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13209-14
All:  52 reference(s)

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