Rab23^opb2
Chemically induced Allele Detail

Summary

• Symbol: Rab23^opb2
• Name: RAB23, member RAS oncogene family; open brain 2
• MGI ID: MGI:2137533
• Synonyms: opb²
• Gene: Rab23 Location: Chr1:33758968-33781645 bp, + strand Genetic Position: Chr1, 12.8 cM
• Alliance: Rab23^opb2 page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU treatment induced a C-to-T mutation at position 238 of the encoded mRNA that altered codon 80 from an arginine to a stop codon (p.R80*). If the peptide is translated, it will lack the domains required for guanine nucleotide and Rab effector binding. (J:70423)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	97 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab23 Mutation: 33 strains or lines available

References

• Original: J:48268 Kasarskis A, et al., A phenotype-based screen for embryonic lethal mutations in the mouse. Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7485-90
• All: 14 reference(s)