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Tg(Pcp2-cre)2Mpin
Transgene Detail
Nomenclature
Symbol: Tg(Pcp2-cre)2Mpin
Name: transgene insertion 2, Max-Planck-Institute of Neurobiology
MGI ID: MGI:2137515
Synonyms: L7-cre, L7Cre-2, pcp2Cre-2
Transgene: Tg(Pcp2-cre)2Mpin  Location: unknown  
Purkinje cell degeneration in Afg3l2tm1Arte/Afg3l2tm1Arte Tg(Pcp2-cre)2Mpin/0 mice

Show the 7 phenotype image(s) involving this allele.

Transgene
origin
Germline Transmission:  Earliest citation of germline transmission: J:66884
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThese transgenic mice express Cre recombinase under the direction of the Purkinje cell-specific L7/Pcp2 promoter. Recombinase activity is observed in most Purkinje cells and some retinal bipolar neurons. Small amounts of activity are observed in an unidentified population of cells of the central nervous system tissue. Recombination is first observed around postnatal day 6 and is fully established 2 to 3 weeks after birth. (J:66884)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pcp2     Summary of all recombinase alleles driven by Pcp2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:66884 Barski JJ, et al., Cre recombinase expression in cerebellar purkinje cells. Genesis. 2000 Nov-Dec;28(3-4):93-8
All:  151 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory