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Gabra1tm1.1Geh
Targeted Allele Detail
Nomenclature
Symbol: Gabra1tm1.1Geh
Name: gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1; targeted mutation 1.1, Gregg E Homanics
MGI ID: MGI:2137421
Synonyms: alpha1-, alpha10
Gene: Gabra1  Location: Chr11:42021766-42073757 bp, - strand  Genetic Position: Chr11, 24.97 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70505
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele is a derivative of Gabra1tm1Geh in which the loxP flanked sequences were deleted in the germline by crossing mice carrying this allele to mice carrying a ubiquitously expressed Cre recombinase. (J:70505)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gabra1 Mutation:  24 strains or lines available
References
Original:  J:70505 Vicini S, et al., GABA(A) receptor alpha1 subunit deletion prevents developmental changes of inhibitory synaptic currents in cerebellar neurons. J Neurosci. 2001 May 1;21(9):3009-16
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory