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Gja8tm1Paul
Targeted Allele Detail
Nomenclature
Symbol: Gja8tm1Paul
Name: gap junction protein, alpha 8; targeted mutation 1, David L Paul
MGI ID: MGI:2137411
Synonyms: alpha8(-), Cx-50-
Gene: Gja8  Location: Chr3:96913566-96926020 bp, - strand  Genetic Position: Chr3, 42.03 cM
Nuclear cataracts in Gja8tm1Paul/Gja8tm1Paul mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50894
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    The entire coding region was replaced with a neomycin resistance cassette. (J:50894)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja8 Mutation:  23 strains or lines available
References
Original:  J:50894 White TW, et al., Targeted ablation of connexin50 in mice results in microphthalmia and zonular pulverulent cataracts. J Cell Biol. 1998 Nov 2;143(3):815-25
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory