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Nr1h4tm1Gonz
Targeted Allele Detail
Nomenclature
Symbol: Nr1h4tm1Gonz
Name: nuclear receptor subfamily 1, group H, member 4; targeted mutation 1, Frank Gonzalez
MGI ID: MGI:2137330
Synonyms: FXR-, FXRalpha-, FXR/BAR -, Fxrtm1Gonz
Gene: Nr1h4  Location: Chr10:89454234-89533585 bp, - strand  Genetic Position: Chr10, 44.98 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64792
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nr1h4 Mutation:  5 strains or lines available
Notes
The ES cell line was not specified, but was purchased from Genome Systems (St. Louis, MO). (Note added 7/26/01: Genome Systems was bought by Incyte.)

References
Original:  J:64792 Sinal CJ, et al., Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis. Cell. 2000 Sep 15;102(6):731-44
All:  86 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory