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Nrp2tm1Ddg
Targeted Allele Detail
Nomenclature
Symbol: Nrp2tm1Ddg
Name: neuropilin 2; targeted mutation 1, David D Ginty
MGI ID: MGI:2137037
Synonyms: Npn-2-, nrp2-
Gene: Nrp2  Location: Chr1:62703285-62818695 bp, + strand  Genetic Position: Chr1, 31.35 cM, cytoband C2
Abnormal lymphatic development in Nrp2tm1Ddg/Nrp2+ Flt4tm1Ali/Flt4+ mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:60149
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 and 1.7 kb upstream of exon 1 were replaced with a neo-derived targeting vector by homologous recombination. Northern blot analysis of homozygous embryos demonstrated that no detectable transcript was expressed. Western blot on extracts derived from brain of homozygous animals did not detect any protein product. (J:60149)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 31 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nrp2 Mutation:  28 strains or lines available
References
Original:  J:60149 Giger RJ, et al., Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins. Neuron. 2000 Jan;25(1):29-41
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory