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Bmp7tm2Rob
Targeted Allele Detail
Nomenclature
Symbol: Bmp7tm2Rob
Name: bone morphogenetic protein 7; targeted mutation 2, Elizabeth J Robertson
MGI ID: MGI:2136986
Synonyms: BMP7lacZ, BMP7/lacZ
Gene: Bmp7  Location: Chr2:172709805-172782114 bp, - strand  Genetic Position: Chr2, 95.54 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50004
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA lacZ gene followed by a neomycin selection cassette replaced a 263 bp DNA fragment containing the endogenous translation start site. A beta-galactosidase protein is expressed from this allele under the control of the endogenous promoter, but the expression pattern does not faithfully reflect the expression pattern of the endogenous gene. (J:50004)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 258 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bmp7 Mutation:  24 strains or lines available
References
Original:  J:50004 Godin RE, et al., Regulation of BMP7 expression during kidney development. Development. 1998 Sep;125(17):3473-82
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory