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Itgaetm1Cmp
Targeted Allele Detail
Nomenclature
Symbol: Itgaetm1Cmp
Name: integrin alpha E, epithelial-associated; targeted mutation 1, Christina M Parker
MGI ID: MGI:2136817
Synonyms: alphaE-, CD103-
Gene: Itgae  Location: Chr11:73090583-73147446 bp, + strand  Genetic Position: Chr11, 45.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:55333
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of exon 10 with a neomycin resistance gene. No Itgae expression is detected in intraepithelial lymphocytes (IEL) by FACS analysis. (J:55333)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Itgae Mutation:  50 strains or lines available
References
Original:  J:55333 Schon MP, et al., Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol. 1999 Jun 1;162(11):6641-9
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory