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Il18tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Il18tm1Aki
Name: interleukin 18; targeted mutation 1, Shizuo Akira
MGI ID: MGI:2136769
Synonyms: Il18-, IL-18, IL-18-, IL-18KO
Gene: Il18  Location: Chr9:50466127-50493140 bp, + strand  Genetic Position: Chr9, 27.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46514
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of exons 3, 4 and 5 with a neomycin resistance gene inserted in frame into exon 3. By Northern blot analysis, mRNA could not be detected in macrophages derived from homozygous mutant mice. By ELISA assay, protein cound not be detected in serum of homozygous mutant mice after intravenous injection of lipopolysaccharide. (J:46514)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 32 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Il18 Mutation:  18 strains or lines available
References
Original:  J:46514 Takeda K, et al., Defective NK cell activity and Th1 response in IL-18-deficient mice. Immunity. 1998 Mar;8(3):383-90
All:  201 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory