Vhltm1Jae
Targeted Allele Detail
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Symbol: |
Vhltm1Jae |
Name: |
von Hippel-Lindau tumor suppressor; targeted mutation 1, Rudolf Jaenisch |
MGI ID: |
MGI:2136645 |
Synonyms: |
2-lox allele, VHL2, VHL+f, VHLf, Vhlh2, Vhlh2lox, Vhlh 2-lox, Vhlh+f, Vhlhfl |
Gene: |
Vhl Location: Chr6:113600955-113608595 bp, + strand Genetic Position: Chr6, 52.81 cM
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Alliance: |
Vhltm1Jae page
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Vascular tumors in Vhltm1.1Jae/Vhl+ livers and vascular lesions in Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/0 mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:67505
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A CMV-hyTK selection cassette flanked by two loxP sites was inserted approximately 2.6 kb upstream of exon 1. A third loxP site was inserted into intron 1. The hygromycin cassette was deleted in ES cells by transient transfection with a vector driving expression of Cre recombinase. The resulting ES cell derivatives with two loxP sites flanking exon 1 were selected and injected into blastocysts to generate the Vhltm1Jae allele.
(J:67505)
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View phenotypes and curated references for all genotypes (concatenated display).
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List all tumor models in MMHCdb carrying
Vhltm1Jae
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Original: |
J:67505 Haase VH, et al., Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1583-8 |
All: |
182 reference(s) |
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