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Targeted Allele Detail
Symbol: Vhltm1Jae
Name: von Hippel-Lindau tumor suppressor; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:2136645
Synonyms: 2-lox allele, VHL2, VHL+f, VHLf, Vhlh2, Vhlh2lox, Vhlh 2-lox, Vhlh+f, Vhlhfl
Gene: Vhl  Location: Chr6:113623994-113631634 bp, + strand  Genetic Position: Chr6, 52.81 cM
Vascular tumors in Vhltm1.1Jae/Vhl+ livers and vascular lesions in Vhltm1Jae/Vhltm1Jae Speer6-ps1Tg(Alb-cre)21Mgn/0 mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:67505
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA CMV-hyTK selection cassette flanked by two loxP sites was inserted approximately 2.6 kb upstream of exon 1. A third loxP site was inserted into intron 1. The hygromycin cassette was deleted in ES cells by transient transfection with a vector driving expression of Cre recombinase. The resulting ES cell derivatives with two loxP sites flanking exon 1 were selected and injected into blastocysts to generate the Vhltm1Jae allele. (J:67505)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 25 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Vhl Mutation:  12 strains or lines available
Original:  J:67505 Haase VH, et al., Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):1583-8
All:  154 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory