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Targeted Allele Detail
Symbol: Ren1tm1Afu
Name: renin 1 structural; targeted mutation 1, Akiyoshi Fukamizu
MGI ID: MGI:2136642
Synonyms: renin-
Gene: Ren1  Location: Chr1:133350510-133360325 bp, + strand  Genetic Position: Chr1, 57.91 cM
Ren1tm1Afu/Ren1tm1Afu mice exhibit kidney abnormalities

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:59299
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ-neomycin reistance cassette replaced the first three exons. Northern blot analysis of kidney did not detect RNA in homozygous mutant mice. (J:59299)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ren1 Mutation:  24 strains or lines available
Original:  J:59299 Yanai K, et al., Renin-dependent cardiovascular functions and renin-independent blood-brain barrier functions revealed by renin-deficient mice. J Biol Chem. 2000 Jan 7;275(1):5-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory