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Targeted Allele Detail
Symbol: Agttm1Afu
Name: angiotensinogen (serpin peptidase inhibitor, clade A, member 8); targeted mutation 1, Akiyoshi Fukamizu
MGI ID: MGI:2136636
Synonyms: AgKO, Agt-KO, Angt-KO, ATG-
Gene: Agt  Location: Chr8:124556587-124569706 bp, - strand  Genetic Position: Chr8, 72.81 cM
Germline Transmission:  Earliest citation of germline transmission: J:21887
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 2, containing the initiation codon and sequences encoding amino acids 1-138, was replaced with a neomycin resistance gene. Northern blot analysis demonstrated that the encoded transcript was not detectable in liver of homozygous mice. (J:21887)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 23 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Agt Mutation:  8 strains or lines available
Original:  J:21887 Tanimoto K, et al., Angiotensinogen-deficient mice with hypotension. J Biol Chem. 1994 Dec 16;269(50):31334-7
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory