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Tp(Y)1CtSxr-b
Spontaneous Allele Detail
Nomenclature
Symbol: Tp(Y)1CtSxr-b
Name: transposition, Chr Y, Cattanach 1; Sex reversed, b variant
MGI ID: MGI:2136318
Synonyms: HY-, Sxr'
Gene: Tp(Y)1Ct  Location: unknown  Genetic Position: ChrY, Syntenic
Mutation
origin
Strain of Origin:  T16H stock
Mutation
description
Allele Type:    Spontaneous
Mutations:    Deletion, Translocation
  Tp(Y)1CtSxr-b involves 3 genes/genome features (Hya, Zfy1, Zfy2) View all
 
Mutation detailsAt least five loci map to the Tp(Y)1Ct segment: Hya, Spy, Tdy, Zfy1, and Zfy2. The Tp(Y)1CtSxr-b variant retained the testis determining gene, Sry, but lost the H-Y antigen-determining gene, Hya. This chromosomal variant also appears to lack one of the Y-linked zinc finger genes, Zfy1 but retains the other, Zfy2. The formation of Tp(Y)1CtSxr-b from Tp(Y)1CtSxr-a was later shown to be due to unequal crossing over between Zfy1 and Zfy2, resulting in a fusion gene and a small interstitial deletion. XX females carrying this transposition variant are sex-reversed but do not express Y Chromosome linked transplantation antigen, Hya. (J:9332)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tp(Y)1Ct Mutation:  4 strains or lines available
References
Original:  J:7662 McLaren A, et al., Male sexual differentiation in mice lacking H-Y antigen. Nature. 1984 Dec 6-12;312(5994):552-5
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory