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Targeted Allele Detail
Symbol: Abcb11tm1Wng
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 11; targeted mutation 1, Renxue Wang
MGI ID: MGI:2136289
Synonyms: spgp-
Gene: Abcb11  Location: Chr2:69068626-69172960 bp, - strand  Genetic Position: Chr2, 39.69 cM
Hepatocyte and bile canalicular abnormalities in Abcb11tm1Wng/Abcb11tm1Wng mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:67548
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe N-terminal ATP-binding domain, corresponding to amino acids 454-478, was deleted and replaced with a neo cassette. The construct introduced three missense mutations and a premature stop codon at position 454. Western analysis showed no detectable protein in homozygous mice. (J:67548)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcb11 Mutation:  49 strains or lines available
Original:  J:67548 Wang R, et al., Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis. Proc Natl Acad Sci U S A. 2001 Feb 13;98(4):2011-6
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory